Handy Smurf has created a revolutionary invention: SmurfoMix! However, it is missing a key ingredient - the Green Stone, which is in Gargamel's greedy clutches. Handy Smurf and his team go in search of the famous stone in Gargamel's laboratory, but due to a fatal mistake, it explodes and its fragments scatter throughout the Cursed Land. The green stone not only unleashed incredible abilities to copy and decompose matter, but also freed the evil Stolas. A team of 4 Smurfs must find the shards of the Green Stone and put them back together before it plunges the world into chaos.